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A liver sinusoid is a type of capillary known as a sinusoidal capillary, discontinuous capillary or sinusoid, that is similar to a fenestrated capillary, having discontinuous endothelium that serves as a location for mixing of the oxygen-rich blood from the hepatic artery and the nutrient-rich blood from the portal vein. SIU SOM Histology GI
The liver sinusoid has a larger caliber than other types of capillaries and has a lining of specialised endothelial cells known as the liver sinusoidal endothelial cells (LSECs), and . The cells are porous and have a scavenging function. The LSECs make up around half of the non-parenchymal cells in the liver and are flattened and fenestrated. LSECs have many fenestrae that gives easy communication between the sinusoidal lumen and the space of Disse. They play a part in filtration, endocytosis, and in the regulation of blood flow in the sinusoids.
The Kupffer cells can Phagocytosis foreign material such as bacteria. Hepatocytes are separated from the sinusoids by the space of Disse. Hepatic stellate cells are present in the space of Disse and are involved in fibrosis in response to liver damage.
Defenestration happens when LSECs are lost rendering the sinusoid as an ordinary capillary. This process precedes fibrosis.
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